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NIFTP.orgTM The Non-Invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features

The incidence of differentiated thyroid cancer has increased in all developed healthcare systems due mainly to a combination of increased use of diagnostic ultrasound & a shift over time in pathological criteria for diagnosis of thyroid cancer.

In 2015-16 an international consensus group led by Prof. Y. Nikiforov from The University of Pittsburgh met to address one aspect of this, the pathological diagnosis of follicular variant of papillary carcinoma (FVPTC) & encapsulated follicular variant of papillary carcinoma (eFVPTC).The working group comprised 24 experienced thyroid pathologists from 7 countries, 2 endocrinologists, a surgeon, a psychiatrist, a molecular pathologist, a biostatistician & a cancer survivor.

The incidence of encapsulated variant of papillary carcinoma has increased & accounts for 10-20% of all newly diagnosed thyroid cancers in Europe & North America.

The diagnosis of eFVPTC is challenging & controversial, based on the nuclear features, which are subjective & controversial with high interobserver variability.

FVPTC & eFVPTC show indolent behaviour and are genetically different from infiltrative tumours.